Journal Club

Mondays at Noon in the Neuroscience Library: Lunch Sponsored by the CNIR!

The purpose of this journal club is to critically discuss the current literature relevant to CNIR and to gain experience with an oral presentation of data and comments in a mixed forum not unlike that at scientific meetings. All NIP trainees are required to attend.

Papers are disseminated the week prior to the presentation to all interested researchers. Once a semester an ethics discussion will occur instead of a scientific paper. The purpose of the ethics component is to demonstrate the consequences of unethical scientific behavior on the research community and on the public perception of science.

Fall 2018 Presentations

September 17
Cameron McDay (NIP trainee). Rapid and widespread white matter plasticity during an intensive reading intervention. Huber et al., 2018, Nature Communications, DOI: 10.1038/s41467-018-04627-5.

September 24
Laya Rajan (NIP trainee). Network connectivity determines cortical thinning in early Parkinson’s disease progression. Yau et al., 2018, Nature Communications, |DOI: 10.1038/s41467-017-02416-0

October 1
Mondona McCann (NIP trainee). Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Faraco et al., 2018, Nature Neuroscience, 21:240-249.

October 8

October 15
Deran Erdengiz (NIP trainee). A53T mutant alpha-synuclein induces tau dependent postsynaptic impairment independent of neurodegenerative changes. Teravskis et al., 2018, J Neurosci, 10.1523/JNEUROSCI.0344-18.2018.

October 22
Lorenzo Bozzelli (NIP trainee). Microglia play an active role in obesity-associated cognitive decline. Cope et al., 2018, J Neurosci, 38 (41) 8889-8904; DOI:

October 29
Steph Sloley (NIP trainee). Reduced microglial activity and enhanced glutamate transmission in the basolateral amygdala in early CNS autoimmunity. Acharjee et al., 2018, J Neurosci, 38(42):9019-9033.

November 5
George Melchor (IPN student). Modulation of porteoglycan receptor PTPsigma enhances MMP-2 activity to promote recovery from multiple sclerosis. Luo et al., 2018, Nature Communications, 9:4126.

November 12

November 19
Mondona McCann & Laya Rajan (NIP trainees). Ethics discussion ‘Court-ordered CNS intervention’.

November 26
Karli Wensel (IPN student). Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice. Thomas et al., 2017. PNAS, 114(15):E3139-E3148.

December 3
Andrew Speidell (IPN student). CREST in the Nucleus Accumbens Core regulates cocaine conditioned place preference, cocaine-seeking behavior, and synaptic plasticity. Alaghband et al., 2018, J Neurosci, 38(44):9514-9526.

Fall 2017 Presentations

September 15
Kathy Maguire-Zeiss (Faculty). ERK/MAPK signaling is required for pathway-specific striatal motor functions. Hutton et al., 2017, J Neurosci 37:8102-8115.

September 22
Erin Wenzel (Trainee). Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway. Trajkovic et al., 2017, J Neurosci 37:9000-9012.

September 29
No JC; IPN Retreat

October 6
Lorenzo Bozzelli (2017-2018 Trainee). Zika virus has oncolytic activity against glioblastoma stem cells. Zhu et al., 2017, J Exp Med 10:2843-2857.

October 13
Carrie Leonard (Post-doc). Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs. Orefice et al., 2016, Cell 166:299-313.

October 20
Kaela Singleton (2017-2018 Trainee). Microglia are irrevlevant for neuronal degeneration and axon regeneration after acute injury. Hilla et al., 2017, J Neurosci, 37:6113-6124.

October 27
Alberto Sepulveda-Rodriguez (IPN Student). α2δ-1 Signaling Drives Cell Death, Synaptogenesis, Circuit Reorganization, and Gabapentin-Mediated Neuroprotection in a Model of Insult-Induced Cortical Malformation. Lau et al., 2017, eNeuro; 10.1523/ENEURO.0316-17.2017.

November 3
Cameron McKay (2017-2018 Trainee). Socioeconomic Status and Reading Disability: Neuroanatomy and Plasticity in Response to Intervention. Romeo et al., 2017, Cerebral Cortex, 1-16.

November 10
Stephanie Sloley & Deran Erdengiz (2017-2018 Trainees) Ethics discussion with a focus on cognitive enhancement.

November 18
Lanier Heyburn (Trainee). Neural stem cell transplantation induce stroke recovery by upregulating glutamate transporter GLT-1 in astrocytes. Bacigaluppi et al., 2016, J Neuroscience, 36(41):10529-10544.

November 24
Canceled – Happy Thanksgiving!

December 1
Stephanie Sloley  (2017-2018 Trainee). Fibrinogen activates BMP signaling in oligodendrocyte progenitor cells and inhibits remyelination after vascular damage. Petersen et al., 2017, Neuron, 96:1-10.

December 8
Deran Erdengiz   (2017-2018 Trainee). a-Synuclein amyloids hijack prion protein to gain cell entry, facilitate cell-to-cell spreading and block prion replication. Aulic et al., 2017, Scientific Reports, Aug(30); 7:10050.

December 15
John Partridge (Faculty). Cell-autonomous excitation of midbrain dopamine neurons by endocannabinoid-dependent lipid signaling. Gantz and Bean, 2017, Neuron, March 22; 93(6): 1375-1387.

December 22
No JC – Happy Holidays